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Madhan Kumar M
Currently pursuing as Scientist B at National JALMA Institute for Leprosy and Other
Mycobacterial Diseases (ICMR), Tajganj, Agra (from 2013 till date).
EDUCATION
National Institute for Research in Tuberculosis (NIRT), Chennai
PhD, Immunology
University of Madras, Chennai
MSc MPhil, Biochemistry
University of Madras, Chennai (D G Vaishnav College)
BSc, Botany
AWARDS AND HONOURS
Council of Scientific and Industrial Research (CSIR) Fellowship 2004-2008
RESEARCH EXPERIENCE
Postdoctoral Research: National Institute of Epidemiology, Tamilnadu, India
Chennai 2011-2013
Project: “HIV sentinel surveillance in southern states of India”
Collection, analysis and interpretation of data on HIV prevalence in southern
states of India (Andhra Pradesh, Karnataka, Kerala, Orissa, Pondicherry,
Tamilnadu)
Worked as Scientist C in NACO project at NIE under Dr. B. Nagaraju
Postdoctoral Research: Madurai Kamaraj
University, Madurai Tamilnadu, India
2010-2011
Project: “Identification of biomarkers for Primary Open Angle Glaucoma (POAG)”
Studied 2D patterns of IgY14-depleted serum profiles of POAG patients and
individuals with cataract (controls)
Mass spectrometric studies (MALDI-TOF) on serum of POAG patients and
individuals with cataract (controls)
Research Associate with Dr.K.Dharmalingam in DBT project
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Doctoral Research: National Institute for Research
in Tuberculosis (NIRT), Chennai Tamilnadu, India
2004-2009
Thesis: “Immune response to ESAT-6 and CFP-10 in pulmonary tuberculosis”
Epitope mapping of two proteins using overlapping peptides covering entire
protein sequences using peripheral blood mononuclear cells (PBMCs)from
pulmonary TB patients and healthy household contacts
Flow cytometric analysis of peptide-stimulated PBMCs – proliferation, cytokine
profiles, memory marker profiles
LDH-based Cytotoxicity studies on peptide stimulated PBMCs
Bioinformatic analysis of peptide binding with different HLA types
HLA typing of pulmonary TB patients and healthy household contacts
Graduate student with Dr. Alamelu Raja
Postgraduate Research: University of Madras, Chennai Tamilnadu, India
2001-2002
Mphil Thesis: “Effect of Ulva lactuca (Chlorophyceae) on D-Galactosamine induced
liver damage in rats”
Methanolic extract of Ulva lactuca
Investigated biochemical parameters related to liver damage in controls and algal
extract treated rats
Histopathological studies on damaged and control liver of rats
Research student with Dr. T. Devaki
Msc Thesis: “Effect of Diltiazem (Ca
2+
channel blocker) and Lisinopril (ACE inhibitor)
on isoproterenol induced Myocardial infarction (MI) in rats”
Combined effect of the drugs on MI studied by analyzing biochemical parameters
and histopathology
Research student with Dr. T. Devaki
TEACHING EXPERIENCE
Instructor: Basic Biology for Bioinformatics students, University of Madras, Chennai
2003
- Lectures and discussion sessions
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PUBLICATIONS
Parkash O, Agrawal S, Madhan Kumar M. T regulatory cells: Achilles' heel of
Mycobacterium tuberculosis infection? Immunol Res. 2015 Jul;62(3):386-98.
.
Madhan Kumar M, Meenakshi N, Jagadish C Sundaramurthi , Gurvinder Kaur,
Narinder K Mehra, Alamelu Raja. Immune response to Mycobacterium tuberculosis
specific antigen ESAT-6 among south Indians. Tuberculosis (Edinb). 2010 Jan;90(1):60-
9. Epub 2009 Nov 27.
Madhan Kumar M, Jagadish C Sundaramurthi, Narinder K Mehra, Gurvinder Kaur,
Alamelu Raja. Cellular immune response to Mycobacterium tuberculosis-specific antigen
culture filtrate protein-10 in south India. Med Microbiol Immunol. 2010 Feb;199(1):11-
25. Epub 2009 Nov 10.
Madhan Kumar M, Alamelu Raja. Cytotoxicity responses to selected ESAT-6 and
CFP-10 peptides in tuberculosis Cell Immunol. 2010;265(2):146-55.
Madhan Kumar murthy, Tamilmani kaliappan, Alamelu Raja. Cytokine and chemokine
responses to selected ESAT-6 and CFP-10 peptides in tuberculosis. J Interferon Cytokine
Res. 2011; 31(3): 299-307.
Madhan Kumar Murthy, R. Parasa, A. Deenadayalan, P. Sharma, A. Raja. Evaluation
of the diagnostic potential of region of deletion-1–encoded antigen culture filtrate
protein-10 in pulmonary tuberculosis Diag Microbiol Infect Dis. 2007; 59(3): 295-302.
Ramana Rao PV, Madhan Kumar M, Basirudeen S, Sharma P, Soumya S, Alamelu
Raja. Improved diagnosis of tuberculosis in HIV-TB patients using RD1 encoded antigen
CFP-10. Int J Infect Dis. 2009; 13(5):613-22.
PRESENTATIONS IN CONFERENCES
International symposium on emerging trends in tuberculosis research- biomarkers, drugs
& vaccine held at ICGEB, New Delhi, India (December 1-3, 2008) and presented a poster
entitled “Immune response to Mycobacterium tuberculosis specific region of deletion-1
(RD-1) antigen ESAT-6”.
34
th
Annual conference of the Indian Immunology Society and HIV immunology
Symposium held at National AIDS Research Institute (16
th
- 18
th
December, 2007 at Pune,
India) and presented a poster titled “CD4 and CD8 T cell responses to overlapping
peptides of ESAT-6 and CFP-10”.
Participated and presented a poster in the 32nd Annual conference of Indian Immunology
Society (IMMCON-2005), PGIMER, Chandigarh, India.