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Name: Om Parkash
Date of Birth: 15-04-1955
Date of joining ICMR: 17-9-1981
Present Post: Scientist-F
Date of joining the present post: 01-9-2013
Discipline: Immunology
Office Address: National JALMA Institute for Leprosy & Other Mycobacterial Diseases,
TajGanj, Agra-282004, Uttar Pradesh, INDIA
Phone: +91-562-2331751-54 Ext.204; +91-562-2231248 Mob: 09927847580; Fax: (Off):
91-562-2331755
Educational Qualification from First Degree Onwards: B.Sc (Hons) Med. Lab.
Technology degree from AIIMS, Delhi, in 1977; M.Sc (Microbiology) degree from HAU,
Hissar, in 1980 and PhD degree with research topic on “An in vitro study on interaction of
mycobacteria with human complement system” , Agra University, Agra in 1989.
Research Experience: Since 1981, total research experience is more than 34 years in the
field of Immunology of Leprosy and Tuberculosis while working at JALMA institute (named
differently at different time points: Central JALMA Institute for Leprosy Agra, Central
JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, National JALMA
Institute for Leprosy and Other Mycobacterial Diseases, Agra).
Membership of Professional Societies/Committees: (a). Life member of Indian
Immunology Society (IIS) (b). Life member of Society for Immunology and
Immunopathology (SIIP) (c). Ordinary member of International Society for Infectious
Diseases (ISID), USA (d). Honorary member (for one year 2010) of “International Union
against tuberculosis and lung Diseases, France.
Conferences: Participated in 75 National and International
Conferences/Symposia/Seminars/Workshops and other scientific events. From 2012 till
April, 2016 participated in following scientific events:
1. Delivered a lead talk on “Proteomics for dissection of Mycobacterium leprae antigens” in
the National Conference on Emerging Trends in Biotechnology and Pharmaceutical
Research, held on Dec. 18-2-2012, at Mangalayatan University, Aligarh, Uttar Pradesh, India
2. Attended and Delivered oral presentation on “Immunoproteomic analysis of cell membrane
of Mycobacterium lepraein the 5
th
Congress of the Federation of Immunological Societies
of Asia Oceania (FIMSA) held at New Delhi, from 14-17 March, 2012.
3. Attended and Delivered an invited talk on “Flow cytometry based analysis of cytokines
profile” in the National Conference on Phytomedicine an alternative of modern medicine and
their molecular expression held at GLA University, Mathura, Uttar Pradesh, India on Dec.
16-2-2013 to 17-2-13.
4. Delivered a lead presentation/talk on “Interferon gamma as a biomarker for diagnosis of
tuberculosis: current status” in International symposium on latest trends in
immunomodulation held on Dec. 22-12-2013 to 24-12-2013 at Rajasthan University of
Veterinary and Animal Sciences, Bikaner, Rajasthan , India.
5. On 02-12-2013, acted as an invited Guest on the occasion of “Biotech Day” celebrated at
GLA University, Mathura, Uttar Pradesh, India and delivered a lecture on “Interferon
gamma as a biomarker for detection of Mycobacterium tuberculosis infection: pros and cons”
6. Delivered an invited guest lecture on “Analysis of intracellular and surface biomolecules
by flow cytomtery” on the inaugural day (25-2-2014) of two Days 25-02-2014 and 26-02-
2014) workshop on “Biotechnology & Microbiology Techniques" at Department of
Biotechnology, GLA University, Mathura, Uttar Pradesh, India.
7. Delivered an invited lecture on T regulatory cells: an overview with special emphasis on
tuberculosis” during International Conference on Life Sciences, Informatics, Food and
Environment IC LIFE 2014 held at Jaypee Institute of Information Technology, NOIDA,
Uttar Pradesh, India from 29
th
to 30
th
August, 2014
8. On 31
st
October, 2014, delivered an invited lecture on “T regulatory cells and efficacy of
BCG as an anti TB vaccine” in a Session of Indian Association of Veterinary
Microbiologists, Immunologists and Specialists in Infectious Diseases held on 31
st
October at
GLA University, Mathura, Uttar Pradesh, India. Also, acted as a co-chaired a session during
the conference.
9. On 29-4-15, participated in Immunology World Day celebration in GLA University,
Department of Biotechnology and delivered a lecture on “BCG and Tregs” and acted as one
of the judges for evaluation of posters hanged by students for award.
10. On 29-4-16, participated in Immunology World Day celebration in GLA University,
Department of Biotechnology and delivered a lecture on “Understanding Vaccines against
infectious diseases: an overview” and acted as one of the judges for evaluation of oral
presentations and posters hanged by students for award.
Awards/ Honours: (a). In recognition of my contributions towards Immunology, the award
“Fellow of Society for Immunology and Immunopathologyn (FSIIP)” was conferred upon me
in February, 2007 (b). In recognition of my contributions towards serological detection of
leprosy, the ICMR award “JALMA Trust Oration award” 2006 was awarded to me in 2009.
(c). Photon publishers awarded “Thomas Edison Award-2014” in the domain of Diabetes and
Health for Inspiration and Knowledge Distribution among young research scholars.
Foreign visits: Have visited: (i) United Kingdom in 1991 (participated in Workshop), (ii) the
Netherlands in 1996 (for research Training), (iii) U.S.A. in 2001 (for Training related to flow
cytometry). & (iv) Singapore in 2002 (participated in conference).
Publications:
1. Om Parkash, Ramanathan, V.D. and Sengupta, U. (1983). A sensitive method for
detection of complement activation by particulate material. Lep. Sci. Memo. L-1188/1
2. Om Parkash, Ramanathan, V.D. and Sengupta, U. (1983). Use of immunofluorescence
technique to demonstrate complement activation in vitro by microbes. Ind. J. Exp. Biol. 21:
674.
3. Ramanathan, V.D., Om Parkash, Ramu, G. et al (1984). Isolation and analysis of
circulating immune-complexes in leprosy. Clin. Immunol. Immunopath. 32:261.
4. Om Parkash, Ramanathan, V.D. and Sengupta, U. (1986). Phenolphthalein
monophosphate as an alternative substrate in enzyme linked immunosorbent assays involving
alkaline phosphatase. Clin. Chem. 32: 894.
5. Ramanathan, V.D., Sharma, P, Om Parkash et al (1987). Studies on complement
activation and immune-complexes in reactions in leprosy. Proc. of Indo-UK Symposium on
Leprosy, held at CJIL, Agra, April, 7-10, p.11.
6. Om Parkash, Ramanathan, V.D, Singh, D.P. and Sengupta, U. (1987) Activation of the
alternative pathway of the complement system by mycobacteria. Curr. Sci. 56: 968.
7. Om Parkash, Ramanathan, V.D. Singh, D.P. and Sengupta, U. (1988) Effect of
antimycobacterial antibodies on activation of alternative pathway of the human complement
system. FEMS Microb. Lett. 55: 225.
8. Om Parkash, Sreevatsa and Sengupta, U. (1990). An attempt to demonstrate antinerve
antibodies in leprosy sera using rabbit nerve as an antigen. Int. J. Lep. 58: 129.
9. Ramanathan, V.D.,Om Parkash, Tyagi, P. et al (1990).Activation of the human
complement system by phenolic glycolipid-1 of Mycobacterium leprae. Microb. Patho. 8:
403.
10. Om Parkash (1990). Interaction between the alternative pathway of the complement
system and mycobacteria. CJIL Quart. Bull. ix (2):1.
11. Om Parkash, Katoch, K. and Sengupta, U. (1990). Terminal complement complex in
plasma of leprosy patients. Acta Lep. 7: 221.
12. Om Parkash and Sengupta, U. (1991). Survival of Mycobacterium leprae in
mononuclear phagocytes: A possible role of complement system. Acta Lep. 7: 375.
13. Parkash, O., Ramanathan, V.D., Mukherjee, A. and Sengupta, U. (1992). A study on
viability of mycobacteria after treating them with complement system. Acta. Lep. 8:29.
14. Om Parkash and Sengupta, U. (1992). Possible roles of anti Mycobacterium leprae
antibodies in suppression of the cell mediated immune response against M.leprae. Immunol.
Today, 13:513.
15. J. Bhattacharya, N.Krishnan, A.K. Chandra, Om Parkash and U. Sengupta (1993).Use of
slide agglutination test for the detection of nuclear polyhedrosis virus of silkworm, Bombyx
mori L. Curr. Sci. 65: 639.
16. Om Parkash, B.K.Girdhar,and U. Sengupta. (1993). Serum lactoferrin in lepromatous
leprosy patients. Lep. Rev. 64: 295-301.
17. P. Desikan, Om Parkash and P. Narang (1994). The role of antiperipheral nerve
antibodies in nerve damage in leprosy. Lep. Rev. 65: 222-230.
18. Om Parkash (1994).Immunoblotting: An introduction. East. Pharm. 37:41-43.
19 Om Parkash (1994). AIDS: Some important facts. (Written in Hindi). Vigyan Ganga,
Sept., 1994, 20-21.
20. Om Parkash (1994). Kushtha rog kya hai. (Written in Hindi) Prerna, 1: 15-17.
21. Om Parkash (2001) Anthrax: Kuch Jankariyan (written in Hindi). Prerna, 8:6
22. Om Parkash, V.Chaturvedi, B.K.Girdhar and U.Sengupta (1995). A study on
performance of two serological assays for diagnosis of leprosy patients. Lep Rev. 66: 26-30.
23. Om Parkash, Ramanathan, V.D. and SenGupta, U. (1993). Interaction between human
complement system and mycobacteria. In Tropical Diseases: Molecular Biology and Control
Strategies, edit. S.Kumar, A.K. Sen, G.P.Dutta and R. N. Sharma. Pub. Inf. Dir. CSIR,
Delhi, 1994, pp. 648-654.
24. U.Sengupta, V.Chaturvedi, S.Sinha, Om Parkash and B.K.Girdhar (1993).
Demonstration of Mycobacterium leprae antigens in tissues and body fluids and their use in
early detection of leprosy: An overview In Tropical Diseases: Molecular Biology and Control
Strategies, edit. S.Kumar, A.K. Sen, G.P.Dutta and R. N. Sharma. Pub. Inf. Dir. CSIR,
Delhi, 1994, pp. 588-591
25. P. Desikan, Om Parkash et al (1995). Role of antineural antibodies in perpetuation of
pre-existing peripheral nerve damage in leprosy. Ind. J. Lep. 67(3): 293-294.
26. Om Parkash (1995). Antileprosy vaccines: an apprehension. Int. J. lep. 63: 572-573.
27. Om Parkash, V.Kumar, et al (1995). Membrane attack complex in thickened cutaneous
sensory nerves of leprosy patrients. Acta Lep. 9: 195-199.
28. Om Parkash (1995).Biological roles of lactoferrin: an overview. Quart. Bull. C.J.I.L.,
xv (2):1-4.
29. Om Parkash, M.K. Beuria, B.K. Girdhar et al (1997). Efforts in diagnosis of early
leprosy using serological techniques. J. Bios. 22:111-116.
30. M.K.Beuria, Om Parkash et al (1998). Levels of IgG subclasses in active and inactive
cases in the disease spectrum of leprosy. Int. Arch. Allerg. Immuno. 115: 61-66.
31. Om Prakash and Sengupta, U. (1998). Detection of Mycobacterium leprae antigen by
enzyme linked immunosorbent assay. In: Proc. of TCDC Int. Training workshop on
Emerging trends in the diagnosis of Infectious Diseases” held at Lucknow from Dec. 7-12,
1998, K. K. Kamboj (ed), pp133-138.
32. Om Parkash (2000) Presence of cytokine in the serum may affect the in vitro response of
T cells. Acta Lep. 12:5.
33. Om Parkash (2001). A study on reproducibility of two serological assays for detection of
M.leprae infection. Inter. J. Lep. 69: 46.
34. Om Parkash (2001) Serology of leprosy employing phenolic glycolipid-1 as an antigen:
some glimpses. In :Advances in Immunology & Immunopathology (eds. R.S. Chauhan,
G.K. Singh & D.K.Agrawal) pp 155-160.
35. Om Parkash and B.K.Girdhar (2001). A comparative and combinatorial study on two
serologicasl assays for detection of Mycobacterium leprae infection. Acta Lep. 12: 63-70
36. Om Parkash (2002). Progress towards detection of Mycobactertum leprae infection,
employing 35kDa antigen: an update. Lep. Rev. 72: 9-19.
37. Om Parkash (2002). Effect of lactoferrin on production of tumor necrosis factor-α. J.
Immuno. Immunopath. 4: 69-71.
38. Om Parkash and T. Singhal (2003). Evaluation of various anticoagulants for whole
blood interferon gamma immunoassay. J. Immunol. Immunopath. 5: 23-25.
39. Om Parkash, H.B. Singh, S. Rai, A.Pandey, M.Sachdeva, S.Kapoor, T. Singhal, G.
Gupta, V.M. Katoch, B.K. Girdhar (2004). Detection of Mycobacterium leprae infection:
some new approaches. J. Immunol. Immunopath. 6(Supplement-1): 13-15.
40. G.Gupta, H.B. Singh, Om Parkash , B.K. Girdhar and V.M. Katoch (2004). Detection of
Mycobacterium leprae DNA in blood samples from leprosy patients: a preliminary study. J.
Immunol. Immunopath. 6 (Supplement-1): 144-145.
41. T. Singhal, Om Parkash, H.B. Singh, V.D. Sharma and V.M. Katoch (2004).
Demonstration of circulating anti-LAM and anti-PGL antibodies, 35kDa Mycobacterium
leprae antigen and gene encoding for 36kDa protein in plasma from leprosy patients. J.
Immunol. Immunopath. 6 (Supplement-1): 127-128.
42. Om Parkash (2004). A strategy to improve the ML flow test for detection of anti-
phenolic glycolipid-1 antibodies. Lep. Rev. 75: 192-193.
43. Om Parkash, H.B. Singh, S. Rai, A. Pandey, V. M. Katoch and B. K. Girdhar (2004).
Detection of Mycobacterium leprae DNA for 36kDa protein in urine from leprosy patients: a
preliminary report. Rev. Inst. Med. Trop. São Paulo. 46: 275-277.
44 Om Parkash (2006) Antibody based assays to detect M.leprae infection. Towards a new
horizon. J. Immunol. Immunopath. 8:10-14.
45.Om Parkash, A. Kumar, A. Nigam, Franken KL, Ottenhoff TH (2006) Evaluation of
recombinant serine-rich 45kDa antigen (ML0411) for detection of antibodies in leprosy
patients. Scand. J. Immunol., 64: 450-455.
46. Om Parkash, A. Kumar, A. Nigam and B.K. Girdhar (2006) Detection of antibodies
against Mycobacterium leprae culture filtrate protein-10 in leprosy patients. J. Med.
Microbiol., 55: 1337-1341.
47. Om Parkash, A. Kumar, A. Kumar, M. L. Arora (2007) Low temperature incubation
improves the performance of anti-phenolic glycolipid-I antibody detecting ELISA in leprosy
patients. J. Med. Microb., 56: 438-440.
48. Om Parkash, R. Pandey, A.Kumar and A. Kumar (2007) Performance of recombinant
ESAT-6 antigen (ML0049) for detection of leprosy patients. Lett. Appl. Microb. 44: 524-
530.
49. A. Kumar, B.K. Girdhar, O. Parkash (2007) Seroreactivity of cytosolic proteins of
Mycobacterium leprae separated by two dimensional gel electrophoresis and
immunoblotting. J. Immunol. Immunopath., 8: 163-164.
50. R. Pandey, O. Parkash, B.K. Girdhar (2007) A comparative study on detection of
Mycobacterium leprae derived anti-recombinant early secretory antigenic target-6 (rESAT-6)
antibodies in leprosy patients, classified clinically and bacteriologically. J. Immunol.
Immunopath., 8: 146-147.
51. Om Parkash, A. Kumar, R. Pandey, Kees.L.M.C. Franken and T. Ottenhoff (2007).
Detection of Mycobacterium leprae infection employing combinatorial approach between
anti-45kDa and modified anti-PGL-I antibody detecting assays. J.Med. Microb. 56: 1129-
1130.
52. Om Parkash, Ajay Kumar, Richa Pandey, Bhawneshwar K. Girdhar, Kees L.M.C.
Franken and Tom H.M. Ottenhoff (2007) Serological heterogeneity against various
Mycobacterium leprae antigens and its use in serodiagnosis of leprosy patients. J.Med.
Microb. 56: 1259-1261.
53. Om Parkash, Avnish Kumar, Richa Pandey, Astha Nigam and Bhawneshwar Kumar
Girdhar (2008). Performance of a lateral flow test for detection of leprosy patients in India.
J.Med. Microb. 57: 130-132.
54. Om Parkash (2008). Interferon gamma based blood tests for detection of
Mycobaacterium tuberculosis infection: an introduction. Published in Compendium for
“Training cum Workshop on Cytokine Assay” held at U.P. Pt. Deen Dayal Upadhyaya
Pashu-Chikitsa Vigyan Vishwavidyalaya Evam Gau Anusandhan Sansthan (DUVASU),
Mathura, INDIA; Page: 81-84.
55. Dheeraj Mohania, Ravinder Nagpal, Manoj Kumar, Aarti Bharadwaj, Shalini Jain,
Marrota Francesco, Vinod Singh, Om Parkash and Hari Om Yadav (2008) Molecular
approaches for identification and characterization of Lactic acid bacteria (LAB). J. Digest.
Dis. 9: 190-198.
56. Om Parkash (2008). Mycobacterium leprae 35kDa antigen and immunoassays for
detection of leprosy: done and to be done. In: Advances in Applied Microbiology (edit: P.
Parihar and L. Parihar), Agrobios, pp: 341-344.
57. Hariom Yadav, Mukesh Yadav, Shalini Jain, Aarti Bhardwaj, Vinod Singh, Om
Parkash, and Francesco Marotta. (2008) Antimicrobial property of a herbal preparation
containing Dalbergia sissoo and Datura stramonium with cow-urine against pathogenic
bacteria. Int. J. Immunopath. Pharmacol, 21: 1017-1024.
58. Om Parkash (2009). Classification of leprosy into multibacillary and paucibacillary
groups: an analysis. FEMS Immunol Med Microbiol, 55: 1-5.
59. Mukesh Yadav, Aarti Bhardwaj, Shalini Jain, Monica Puniya, Vinod Singh, Radha
Tomar, Om Parkash, GBKS Prasad, F Marrota and Hariom Yadav (2009). Biological and
medicinal properties of grapes and its bioactive constituents: New updates. J. Med. Food, 12:
473-484.
60. Om Parkash, B.P. Singh and M.Pai. (2009) Regions of differences encoded antigens as
targets for immunodiagnosis of tuberculosis in humans. Scand. J. Immunol. 70(4); 345-357.
61. Avnish Kumar, B.K. Girdhar, Om Parkash (2010) Immunoproteomic analysis of
Mycobacterium leprae derived cell membrane antigens. Int. J. Biol. Med. Res. 1(4): 242-
247
62. Om Parkash (2010). Proteomics of Mycobacterium leprae towards immunodiagnosis of
leprosy. In: Recent Advances in Immunobiotechnology (edit: R.S Chauhan and
J.M.S.Rana), Society for Immunology and Immunopathology, Institute of Biotechnology,
Patwadangar, Nainital, pp: 71-74.
63. Om Parkash (2011). Serological detection of leprosy employing Mycobacterium leprae
derived serine-rich 45kDa, ESAT-6, CFP-10 and PGL-I: a compilation of data from studies
in Indian populations. Lepr Rev; 82, 383-388
64. R. Nagpal; P. V. Behare; M. Kumar; D. Mohania; M. Yadav; S. Jain; S. Menon; O.
Parkash; F. Marotta; E. Minelli; C JK Henry; H. Yadav. (2012). Milk, milk products and
disease free health: an updated. overview. Crit Rev Food Sci Nutr. 52(4):321-333
65. Om Parkash (2012). Advances in proteomics of Mycobacterium leprae. Scand J
Immunol.75: 369-378.
66. Kumar A , Asthana M, Sharma S, Roy P, Amdekar S, Singh V, Parkash O, Sharma R.
Importance of Using DNA Microarray in Studying Medicinal Plant. Webmed Central
MOLECULAR BIOLOGY, 2012; 3(12):WMC003876
67. Om Parkash (2013).Interferon gamma as a biomarker for diagnosis of tuberculosis:
current status J. Immunol. Immunopath. 15: 38-42.
68. Om Parkash (2014). How to avoid the impact of environmental mycobacteria towards
the efficacy of BCG vaccination against tuberculosis? Int. J. Mycobact. 3: 1-4.
69. Om Parkash (2014). Vaccine against tuberculosis: a view. J.Med. Microb. 63: 777-
779.
70. Yadav M., Parkash O., Singh V., Marotta F., Yadav H., (2014). Naysa Green Tea: A
potential hypoglycemic agent for better management of Diabetes. J. Diab. Health. 107, 200-
205.
71. Kumar, A, Parkash, O., Girdhar, B.K. (2014). Analysis of antigens of Mycobacterium
leprae by interaction to serum IgG, IgM, and IgA response to improve diagnosis of leprosy.
BioMed. Res. Int. Article ID 283278, 1-10.
72. Om Parkash (2015). T regulatory cells and BCG as a vaccine against tuberculosis: an
overview. World J. Vaccines 5: 96-105.
73. Om Parkash, Sonali Agrawal and Madhan Kumar (2015). T Regulatory cells: Achille’s
heel of Mycobacterium tuberculosis infection? Immunol. Res. 62: 386-398
74. Om Parkash (2016). Under performance of anti tuberculosis vaccine MVA85A in BCG-
primed subjects: a commentary. Curr. Immunol. Rev. 12 (1): 56-60.